Drug interactions
Bosentan + Padeliporfin
Severity: Moderate
Bosentan and Padeliporfin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Padeliporfin may inhibit OATP-mediated hepatic uptake of bosentan, increasing its plasma concentrations and hepatotoxicity risk.
What this interaction means in plain words
Bosentan and Padeliporfin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Padeliporfin belongs to Oncology.
Why it happens
Inhibition of OATP1B1/1B3-mediated hepatic uptake of bosentan.
What to do
Withhold bosentan on the infusion day and for at least 24 hours after. Monitor liver function and blood pressure if overlap occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bosentan and Padeliporfin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Padeliporfin
- Acetylsalicylic acid + Padeliporfin Major
- Amiodarone + Padeliporfin Major
- Griseofulvin + Padeliporfin Major
- Glyburide + Padeliporfin Moderate
- Padeliporfin + Repaglinide Moderate
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Cyclosporine Contraindicated
- Bosentan + Glyburide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
Frequently asked questions
Can I take Bosentan with Padeliporfin?
MediHelp rates the interaction as moderate. Bosentan and Padeliporfin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Padeliporfin may inhibit OATP-mediated hepatic uptake of bosentan, increasing its plasma concentrations and hepatotoxicity risk.
How serious is the interaction between Bosentan and Padeliporfin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Withhold bosentan on the infusion day and for at least 24 hours after. Monitor liver function and blood pressure if overlap occurs.
What other medicines interact with Padeliporfin?
MediHelp also lists interactions of Padeliporfin with, for example, Acetylsalicylic acid, Amiodarone, Griseofulvin. The full list is on the Padeliporfin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
