Drug interactions
Padeliporfin + Repaglinide
Severity: Moderate
Padeliporfin and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Padeliporfin inhibits hepatic OATP1B1/1B3 transporters in vitro, potentially raising repaglinide concentrations and the risk of hypoglycemia.
What this interaction means in plain words
Padeliporfin and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Padeliporfin belongs to Oncology; Repaglinide belongs to Endocrine.
Why it happens
Inhibition of OATP1B1/1B3-mediated hepatic uptake of repaglinide.
What to do
Do not give repaglinide on the infusion day or for at least 24 hours afterwards. Monitor blood glucose if exposure cannot be avoided.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Padeliporfin
- Acetylsalicylic acid + Padeliporfin Major
- Amiodarone + Padeliporfin Major
- Griseofulvin + Padeliporfin Major
- Bosentan + Padeliporfin Moderate
- Glyburide + Padeliporfin Moderate
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Padeliporfin with Repaglinide?
MediHelp rates the interaction as moderate. Padeliporfin and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Padeliporfin inhibits hepatic OATP1B1/1B3 transporters in vitro, potentially raising repaglinide concentrations and the risk of hypoglycemia.
How serious is the interaction between Padeliporfin and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give repaglinide on the infusion day or for at least 24 hours afterwards. Monitor blood glucose if exposure cannot be avoided.
What other medicines interact with Padeliporfin?
MediHelp also lists interactions of Padeliporfin with, for example, Acetylsalicylic acid, Amiodarone, Griseofulvin. The full list is on the Padeliporfin page.
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