Drug interactions
Griseofulvin + Temsirolimus
Severity: Moderate
Griseofulvin and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin may lower exposure to temsirolimus and its active metabolite sirolimus, which could reduce antitumor activity.
What this interaction means in plain words
Griseofulvin and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Griseofulvin belongs to Anti Fungals; Temsirolimus belongs to Oncology.
Why it happens
CYP3A4 induction increases metabolism of temsirolimus and sirolimus.
What to do
Use a non-inducing antifungal if possible. If not, monitor response and consider specialist guidance on temsirolimus dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Griseofulvin with Temsirolimus?
MediHelp rates the interaction as moderate. Griseofulvin and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Griseofulvin may lower exposure to temsirolimus and its active metabolite sirolimus, which could reduce antitumor activity.
How serious is the interaction between Griseofulvin and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-inducing antifungal if possible. If not, monitor response and consider specialist guidance on temsirolimus dosing.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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