Drug interactions
Griseofulvin + Trazodone
Severity: Moderate
Griseofulvin and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin may lower trazodone concentrations and weaken antidepressant or hypnotic effects.
What this interaction means in plain words
Griseofulvin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Griseofulvin belongs to Anti Fungals; Trazodone belongs to Central Nervous System.
Why it happens
CYP3A4 induction increases the conversion and clearance of trazodone.
What to do
Monitor clinical response and increase trazodone dose if needed. Reduce the dose after griseofulvin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Griseofulvin with Trazodone?
MediHelp rates the interaction as moderate. Griseofulvin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Griseofulvin may lower trazodone concentrations and weaken antidepressant or hypnotic effects.
How serious is the interaction between Griseofulvin and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and increase trazodone dose if needed. Reduce the dose after griseofulvin is stopped.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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