Drug interactions
Griseofulvin + Ubrogepant
Severity: Moderate
Griseofulvin and Ubrogepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ubrogepant is a CYP3A4 substrate, and inducers reduce its exposure and may reduce efficacy in migraine. Griseofulvin is a weak inducer, so the effect is probably modest.
What this interaction means in plain words
Griseofulvin and Ubrogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Griseofulvin belongs to Anti Fungals; Ubrogepant belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction by griseofulvin increases ubrogepant metabolism.
What to do
Use the higher 100 mg ubrogepant dose per labeling for weak inducers, and reassess efficacy if response is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Other interactions of Ubrogepant
- Clarithromycin + Ubrogepant Contraindicated
- Itraconazole + Ubrogepant Contraindicated
- Ketoconazole + Ubrogepant Contraindicated
- Posaconazole + Ubrogepant Contraindicated
- Ubrogepant + Voriconazole Contraindicated
- Apalutamide + Ubrogepant Major
Frequently asked questions
Can I take Griseofulvin with Ubrogepant?
MediHelp rates the interaction as moderate. Griseofulvin and Ubrogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ubrogepant is a CYP3A4 substrate, and inducers reduce its exposure and may reduce efficacy in migraine. Griseofulvin is a weak inducer, so the effect is probably modest.
How serious is the interaction between Griseofulvin and Ubrogepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the higher 100 mg ubrogepant dose per labeling for weak inducers, and reassess efficacy if response is poor.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporin, Desogestrel-ethinyl estradiol, Dienogest / estradiol valerate. The full list is on the Griseofulvin page.
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