Drug interactions
Griseofulvin + Zonisamide
Severity: Minor
Griseofulvin and Zonisamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin could lower zonisamide concentrations through weak CYP3A4 induction, as CYP3A4 is a major route of zonisamide metabolism. The effect is theoretical but could matter for seizure control.
What this interaction means in plain words
Griseofulvin and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Griseofulvin belongs to Anti Fungals; Zonisamide belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction by griseofulvin may increase zonisamide metabolism.
What to do
Monitor seizure control when griseofulvin is started or stopped, and consider checking zonisamide levels if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Griseofulvin and Zonisamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Griseofulvin
Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Frequently asked questions
Can I take Griseofulvin with Zonisamide?
MediHelp rates the interaction as minor. Griseofulvin and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Griseofulvin could lower zonisamide concentrations through weak CYP3A4 induction, as CYP3A4 is a major route of zonisamide metabolism. The effect is theoretical but could matter for seizure control.
How serious is the interaction between Griseofulvin and Zonisamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control when griseofulvin is started or stopped, and consider checking zonisamide levels if control changes.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
