Drug interactions
Guanfacine + Lurasidone
Severity: Moderate
Guanfacine and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Guanfacine lowers blood pressure and causes sedation, and lurasidone can cause orthostatic hypotension and somnolence. Together they may cause more dizziness, hypotension, bradycardia and drowsiness.
What this interaction means in plain words
Guanfacine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Guanfacine belongs to Cardiovascular; Lurasidone belongs to Central Nervous System.
Why it happens
Additive hypotensive and CNS depressant effects: central alpha-2 agonism plus alpha-1 blockade.
What to do
Monitor blood pressure, heart rate and sedation, particularly during titration. Lower the guanfacine dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Guanfacine
- Clonidine + Guanfacine Major
- Guanfacine + Lofexidine Major
- Aldesleukin + Guanfacine Moderate
- Amiodarone + Guanfacine Moderate
- Amisulpride + Guanfacine Moderate
- Amitriptyline + Guanfacine Moderate
Frequently asked questions
Can I take Guanfacine with Lurasidone?
MediHelp rates the interaction as moderate. Guanfacine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Guanfacine lowers blood pressure and causes sedation, and lurasidone can cause orthostatic hypotension and somnolence. Together they may cause more dizziness, hypotension, bradycardia and drowsiness.
How serious is the interaction between Guanfacine and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and sedation, particularly during titration. Lower the guanfacine dose if symptomatic hypotension occurs.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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