Drug interactions
Guarana + Lisdexamfetamine
Severity: Moderate
Guarana and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Guarana contains caffeine, which adds stimulant effects to lisdexamfetamine. Together they may increase blood pressure, heart rate, anxiety and insomnia.
What this interaction means in plain words
Guarana and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central and sympathetic stimulation from caffeine and amphetamine.
What to do
Advise limiting guarana and other caffeine sources. Monitor blood pressure, heart rate and sleep.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Guarana with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Guarana and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Guarana contains caffeine, which adds stimulant effects to lisdexamfetamine. Together they may increase blood pressure, heart rate, anxiety and insomnia.
How serious is the interaction between Guarana and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise limiting guarana and other caffeine sources. Monitor blood pressure, heart rate and sleep.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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