Drug interactions
Guselkumab + Oxaliplatin
Severity: Moderate
Guselkumab and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Guselkumab modulates immune responses through IL-23 inhibition and oxaliplatin suppresses bone marrow. Combined use may raise infection risk, though clinical data are limited.
What this interaction means in plain words
Guselkumab and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Guselkumab belongs to Miscellaneous; Oxaliplatin belongs to Oncology.
Why it happens
Possible additive immunosuppression from IL-23 blockade and chemotherapy myelosuppression.
What to do
Monitor for infection and blood counts during chemotherapy. Consider holding guselkumab during periods of significant neutropenia or active infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Guselkumab
- Adenovirus types 4 and 7 live + Guselkumab Major
- Bcg vaccine live + Guselkumab Major
- Guselkumab + Influenza virus vaccine quadrivalent intranasal Major
- Guselkumab + Measles mumps and rubella vaccine live Major
- Guselkumab + Measles mumps rubella and varicella vaccine live Major
- Guselkumab + Measles vaccine Major
Frequently asked questions
Can I take Guselkumab with Oxaliplatin?
MediHelp rates the interaction as moderate. Guselkumab and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Guselkumab modulates immune responses through IL-23 inhibition and oxaliplatin suppresses bone marrow. Combined use may raise infection risk, though clinical data are limited.
How serious is the interaction between Guselkumab and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and blood counts during chemotherapy. Consider holding guselkumab during periods of significant neutropenia or active infection.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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