Drug interactions
Guselkumab + Trastuzumab deruxtecan
Severity: Moderate
Guselkumab and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab deruxtecan causes myelosuppression including neutropenia, and guselkumab modulates immune function. Combined use may add to infection risk, though data are lacking. Patients with cancer are already at higher infection risk.
What this interaction means in plain words
Guselkumab and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Guselkumab belongs to Miscellaneous; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive immunosuppression from cytotoxic payload-related neutropenia and IL-23 inhibition.
What to do
Monitor neutrophil counts and signs of infection. Reassess the need for guselkumab during active cancer treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Guselkumab
- Adenovirus types 4 and 7 live + Guselkumab Major
- Bcg vaccine live + Guselkumab Major
- Guselkumab + Influenza virus vaccine quadrivalent intranasal Major
- Guselkumab + Measles mumps and rubella vaccine live Major
- Guselkumab + Measles mumps rubella and varicella vaccine live Major
- Guselkumab + Measles vaccine Major
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Guselkumab with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Guselkumab and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab deruxtecan causes myelosuppression including neutropenia, and guselkumab modulates immune function. Combined use may add to infection risk, though data are lacking. Patients with cancer are already at higher infection risk.
How serious is the interaction between Guselkumab and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and signs of infection. Reassess the need for guselkumab during active cancer treatment.
What other medicines interact with Guselkumab?
MediHelp also lists interactions of Guselkumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Guselkumab page.
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