Drug interactions
Haemophilus influenzae type b vaccine + Leflunomide
Severity: Minor
Haemophilus influenzae type b vaccine and Leflunomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leflunomide may weaken the antibody response to Hib vaccine. The vaccine is non-live, so the concern is reduced protection rather than infection from the vaccine.
What this interaction means in plain words
Haemophilus influenzae type b vaccine and Leflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Leflunomide's antiproliferative effect on lymphocytes reduces vaccine immunogenicity.
What to do
Vaccinate before starting leflunomide when possible. Consider revaccination or serologic checks if protection is important.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Frequently asked questions
Can I take Haemophilus influenzae type b vaccine with Leflunomide?
MediHelp rates the interaction as minor. Haemophilus influenzae type b vaccine and Leflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Leflunomide may weaken the antibody response to Hib vaccine. The vaccine is non-live, so the concern is reduced protection rather than infection from the vaccine.
How serious is the interaction between Haemophilus influenzae type b vaccine and Leflunomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting leflunomide when possible. Consider revaccination or serologic checks if protection is important.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
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