Drug interactions
Haemophilus influenzae type b vaccine + Lomustine
Severity: Moderate
Haemophilus influenzae type b vaccine and Lomustine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomustine-related immunosuppression can blunt antibody responses to the conjugate Hib vaccine. Patients may remain unprotected despite vaccination during chemotherapy.
What this interaction means in plain words
Haemophilus influenzae type b vaccine and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic suppression of lymphocytes and bone marrow reduces vaccine-induced immune response.
What to do
Vaccinate at least 2 weeks before lomustine when possible; otherwise revaccinate about 3 months after chemotherapy once immune function recovers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Haemophilus influenzae type b vaccine with Lomustine?
MediHelp rates the interaction as moderate. Haemophilus influenzae type b vaccine and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomustine-related immunosuppression can blunt antibody responses to the conjugate Hib vaccine. Patients may remain unprotected despite vaccination during chemotherapy.
How serious is the interaction between Haemophilus influenzae type b vaccine and Lomustine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before lomustine when possible; otherwise revaccinate about 3 months after chemotherapy once immune function recovers.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.
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