Drug interactions
Haloperidol + Histrelin
Severity: Moderate
Haloperidol and Histrelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin is a GnRH agonist that suppresses androgens, and androgen deprivation can prolong the QT interval. With haloperidol, which also prolongs QT, the risk of torsades de pointes may rise.
What this interaction means in plain words
Haloperidol and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Histrelin belongs to Musculoskeletal.
Why it happens
Additive QT prolongation from androgen deprivation by histrelin and direct repolarization effects of haloperidol.
What to do
Obtain a baseline ECG and electrolytes and repeat periodically. Correct hypokalemia and hypomagnesemia and reassess if the QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Haloperidol with Histrelin?
MediHelp rates the interaction as moderate. Haloperidol and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Histrelin is a GnRH agonist that suppresses androgens, and androgen deprivation can prolong the QT interval. With haloperidol, which also prolongs QT, the risk of torsades de pointes may rise.
How serious is the interaction between Haloperidol and Histrelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and electrolytes and repeat periodically. Correct hypokalemia and hypomagnesemia and reassess if the QTc lengthens.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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