Drug interactions
Haloperidol + Ziprasidone
Severity: Contraindicated
Haloperidol and Ziprasidone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both antipsychotics prolong the QT interval, and ziprasidone is among the more QT-active agents. Combining them increases the risk of torsades de pointes and sudden cardiac death.
What this interaction means in plain words
Haloperidol and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Haloperidol belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation through hERG potassium channel blockade.
What to do
Do not combine; use a single antipsychotic. If switching, allow appropriate washout and check ECG and electrolytes.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Haloperidol with Ziprasidone?
MediHelp rates the interaction as contraindicated. Haloperidol and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both antipsychotics prolong the QT interval, and ziprasidone is among the more QT-active agents. Combining them increases the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Haloperidol and Ziprasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use a single antipsychotic. If switching, allow appropriate washout and check ECG and electrolytes.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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