Drug interactions
Haloperidol + Indomethacin
Severity: Minor
Haloperidol and Indomethacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Case reports describe marked drowsiness, confusion and disorientation when indomethacin was given with haloperidol. The relationship is poorly characterised and is not consistently observed.
What this interaction means in plain words
Haloperidol and Indomethacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Haloperidol belongs to Central Nervous System; Indomethacin belongs to Musculoskeletal.
Why it happens
The mechanism is not established; additive CNS effects have been proposed.
What to do
Observe for excessive sedation or confusion when starting indomethacin in patients on haloperidol, and consider another analgesic if it occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Indomethacin?
MediHelp rates the interaction as minor. Haloperidol and Indomethacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Case reports describe marked drowsiness, confusion and disorientation when indomethacin was given with haloperidol. The relationship is poorly characterised and is not consistently observed.
How serious is the interaction between Haloperidol and Indomethacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Observe for excessive sedation or confusion when starting indomethacin in patients on haloperidol, and consider another analgesic if it occurs.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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