Drug interactions
Haloperidol + Isavuconazonium
Severity: Moderate
Haloperidol and Isavuconazonium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a moderate CYP3A4 inhibitor and haloperidol is partly metabolized by CYP3A4, so haloperidol exposure may increase. This could heighten adverse effects including QT prolongation and extrapyramidal symptoms. Isavuconazole also shortens the QT interval, which may partly offset the QT risk.
What this interaction means in plain words
Haloperidol and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Isavuconazonium belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated haloperidol metabolism by isavuconazole.
What to do
Monitor for extrapyramidal symptoms, sedation and QTc changes, and consider lowering the haloperidol dose if adverse effects arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Haloperidol with Isavuconazonium?
MediHelp rates the interaction as moderate. Haloperidol and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole is a moderate CYP3A4 inhibitor and haloperidol is partly metabolized by CYP3A4, so haloperidol exposure may increase. This could heighten adverse effects including QT prolongation and extrapyramidal symptoms. Isavuconazole also shortens the QT interval, which may partly offset the QT risk.
How serious is the interaction between Haloperidol and Isavuconazonium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, sedation and QTc changes, and consider lowering the haloperidol dose if adverse effects arise.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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