Drug interactions
Haloperidol + Lapatinib
Severity: Moderate
Haloperidol and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both haloperidol and lapatinib can prolong the QT interval, so together they may increase the risk of torsades de pointes. Risk rises with electrolyte disturbances or heart disease.
What this interaction means in plain words
Haloperidol and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Lapatinib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization (QT interval).
What to do
Check a baseline ECG and correct potassium and magnesium, then repeat ECG during therapy. Avoid intravenous haloperidol and consider alternatives if QTc is markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Haloperidol with Lapatinib?
MediHelp rates the interaction as moderate. Haloperidol and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both haloperidol and lapatinib can prolong the QT interval, so together they may increase the risk of torsades de pointes. Risk rises with electrolyte disturbances or heart disease.
How serious is the interaction between Haloperidol and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and correct potassium and magnesium, then repeat ECG during therapy. Avoid intravenous haloperidol and consider alternatives if QTc is markedly prolonged.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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