Drug interactions
Haloperidol + Lemborexant
Severity: Moderate
Haloperidol and Lemborexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol may modestly raise lemborexant levels via CYP3A4 inhibition, increasing next-day somnolence and CNS depression. Additive sedation is also possible.
What this interaction means in plain words
Haloperidol and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Lemborexant belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated lemborexant metabolism plus additive CNS depression.
What to do
Use the lowest lemborexant dose and monitor for excess sedation and impaired next-day alertness. Counsel patients about driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Haloperidol with Lemborexant?
MediHelp rates the interaction as moderate. Haloperidol and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol may modestly raise lemborexant levels via CYP3A4 inhibition, increasing next-day somnolence and CNS depression. Additive sedation is also possible.
How serious is the interaction between Haloperidol and Lemborexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest lemborexant dose and monitor for excess sedation and impaired next-day alertness. Counsel patients about driving.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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