Drug interactions
Haloperidol + Lenacapavir
Severity: Moderate
Haloperidol and Lenacapavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor and can raise concentrations of CYP3A substrates such as haloperidol, an effect that may persist for months after subcutaneous dosing. Increased haloperidol exposure could heighten extrapyramidal symptoms, sedation and QT prolongation.
What this interaction means in plain words
Haloperidol and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Lenacapavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A-mediated haloperidol metabolism by lenacapavir.
What to do
Monitor for haloperidol adverse effects including QTc prolongation and consider reducing the dose. Remember the inhibitory effect may continue for months after the last lenacapavir injection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Haloperidol with Lenacapavir?
MediHelp rates the interaction as moderate. Haloperidol and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor and can raise concentrations of CYP3A substrates such as haloperidol, an effect that may persist for months after subcutaneous dosing. Increased haloperidol exposure could heighten extrapyramidal symptoms, sedation and QT prolongation.
How serious is the interaction between Haloperidol and Lenacapavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for haloperidol adverse effects including QTc prolongation and consider reducing the dose. Remember the inhibitory effect may continue for months after the last lenacapavir injection.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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