Drug interactions
Haloperidol + Levofloxacin
Severity: Major
Haloperidol and Levofloxacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol and levofloxacin each prolong the QT interval, and together they raise the risk of torsades de pointes. Risk is higher with intravenous haloperidol, high doses, electrolyte imbalance or cardiac disease.
What this interaction means in plain words
Haloperidol and Levofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Haloperidol belongs to Central Nervous System; Levofloxacin belongs to Anti Bacterial.
Why it happens
Additive hERG potassium channel blockade prolonging cardiac repolarization.
What to do
Use an alternative antibiotic where possible. If both are needed, check a baseline ECG, correct electrolytes and monitor the QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Levofloxacin?
MediHelp rates the interaction as major. Haloperidol and Levofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Haloperidol and levofloxacin each prolong the QT interval, and together they raise the risk of torsades de pointes. Risk is higher with intravenous haloperidol, high doses, electrolyte imbalance or cardiac disease.
How serious is the interaction between Haloperidol and Levofloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic where possible. If both are needed, check a baseline ECG, correct electrolytes and monitor the QTc.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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