Drug interactions
Haloperidol + Lurbinectedin
Severity: Moderate
Haloperidol and Lurbinectedin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurbinectedin is cleared mainly by CYP3A4. Haloperidol is a weak CYP3A4 inhibitor, so any rise in lurbinectedin exposure is probably small, though it could increase myelosuppression and hepatotoxicity.
What this interaction means in plain words
Haloperidol and Lurbinectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Lurbinectedin belongs to Oncology.
Why it happens
Possible weak inhibition of CYP3A4-mediated lurbinectedin metabolism by haloperidol.
What to do
Monitor blood counts and liver enzymes during lurbinectedin therapy. Prefer an antipsychotic without CYP3A4 inhibition if a clinically meaningful effect is a concern.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Lurbinectedin
Frequently asked questions
Can I take Haloperidol with Lurbinectedin?
MediHelp rates the interaction as moderate. Haloperidol and Lurbinectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurbinectedin is cleared mainly by CYP3A4. Haloperidol is a weak CYP3A4 inhibitor, so any rise in lurbinectedin exposure is probably small, though it could increase myelosuppression and hepatotoxicity.
How serious is the interaction between Haloperidol and Lurbinectedin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and liver enzymes during lurbinectedin therapy. Prefer an antipsychotic without CYP3A4 inhibition if a clinically meaningful effect is a concern.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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