Drug interactions
Haloperidol + Methohexital
Severity: Moderate
Haloperidol and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a barbiturate anesthetic, and with haloperidol it can enhance sedation, hypotension and respiratory depression. Haloperidol may also lower the seizure threshold, which matters because methohexital can provoke seizure activity.
What this interaction means in plain words
Haloperidol and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Methohexital belongs to Central Nervous System.
Why it happens
Additive central nervous system and cardiovascular depression.
What to do
Titrate methohexital carefully and use continuous monitoring of respiration, blood pressure and oxygenation. Have airway support available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Methohexital
Frequently asked questions
Can I take Haloperidol with Methohexital?
MediHelp rates the interaction as moderate. Haloperidol and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital is a barbiturate anesthetic, and with haloperidol it can enhance sedation, hypotension and respiratory depression. Haloperidol may also lower the seizure threshold, which matters because methohexital can provoke seizure activity.
How serious is the interaction between Haloperidol and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate methohexital carefully and use continuous monitoring of respiration, blood pressure and oxygenation. Have airway support available.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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