Drug interactions
Haloperidol + Milnacipran
Severity: Moderate
Haloperidol and Milnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a serotonergic antidepressant with haloperidol carries a small risk of serotonin syndrome or neuroleptic malignant syndrome. Haloperidol can also prolong the QT interval and extrapyramidal effects may be more noticeable.
What this interaction means in plain words
Haloperidol and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Milnacipran belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic serotonergic and dopaminergic effects; no pharmacokinetic mechanism is established.
What to do
Monitor for serotonin toxicity, neuroleptic malignant syndrome and extrapyramidal symptoms, and consider ECG monitoring in patients with QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Milnacipran
- Isocarboxazid + Milnacipran Contraindicated
- Methylene blue + Milnacipran Contraindicated
- Milnacipran + Phenelzine Contraindicated
- Milnacipran + Procarbazine Contraindicated
- Milnacipran + Rasagiline Contraindicated
- Milnacipran + Safinamide Contraindicated
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Milnacipran?
MediHelp rates the interaction as moderate. Haloperidol and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a serotonergic antidepressant with haloperidol carries a small risk of serotonin syndrome or neuroleptic malignant syndrome. Haloperidol can also prolong the QT interval and extrapyramidal effects may be more noticeable.
How serious is the interaction between Haloperidol and Milnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin toxicity, neuroleptic malignant syndrome and extrapyramidal symptoms, and consider ECG monitoring in patients with QT risk factors.
What other medicines interact with Milnacipran?
MediHelp also lists interactions of Milnacipran with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Milnacipran page.
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