Drug interactions
Haloperidol + Mitotane
Severity: Moderate
Haloperidol and Mitotane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane strongly induces CYP3A4, which can substantially lower haloperidol concentrations and lead to loss of antipsychotic control. The induction effect may persist for weeks after mitotane is stopped.
What this interaction means in plain words
Haloperidol and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Mitotane belongs to Oncology.
Why it happens
Induction of CYP3A4-mediated haloperidol metabolism by mitotane.
What to do
Monitor psychiatric response and consider increasing haloperidol dose, with ECG and serum level checks if available. Reduce the dose again if mitotane is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Haloperidol with Mitotane?
MediHelp rates the interaction as moderate. Haloperidol and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane strongly induces CYP3A4, which can substantially lower haloperidol concentrations and lead to loss of antipsychotic control. The induction effect may persist for weeks after mitotane is stopped.
How serious is the interaction between Haloperidol and Mitotane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric response and consider increasing haloperidol dose, with ECG and serum level checks if available. Reduce the dose again if mitotane is discontinued.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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