Drug interactions
Haloperidol + Naldemedine
Severity: Minor
Haloperidol and Naldemedine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naldemedine is metabolized by CYP3A4, and haloperidol is not a clinically relevant CYP3A4 inhibitor, so an increase in naldemedine exposure is unlikely. No important interaction is expected.
What this interaction means in plain words
Haloperidol and Naldemedine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Haloperidol belongs to Central Nervous System; Naldemedine belongs to Gastrointestinal Tract.
Why it happens
No established mechanism; haloperidol is only a weak CYP3A4 inhibitor in vitro.
What to do
No dose adjustment is needed; monitor for gastrointestinal adverse effects or opioid withdrawal symptoms as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Haloperidol with Naldemedine?
MediHelp rates the interaction as minor. Haloperidol and Naldemedine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Naldemedine is metabolized by CYP3A4, and haloperidol is not a clinically relevant CYP3A4 inhibitor, so an increase in naldemedine exposure is unlikely. No important interaction is expected.
How serious is the interaction between Haloperidol and Naldemedine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for gastrointestinal adverse effects or opioid withdrawal symptoms as usual.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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