Drug interactions
Haloperidol + Naloxegol
Severity: Moderate
Haloperidol and Naloxegol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naloxegol is a CYP3A4 substrate and haloperidol may weakly inhibit this enzyme, possibly increasing naloxegol exposure. Higher levels may cause abdominal pain, diarrhea and opioid withdrawal symptoms.
What this interaction means in plain words
Haloperidol and Naloxegol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Naloxegol belongs to Gastrointestinal Tract.
Why it happens
Possible weak CYP3A4 inhibition by haloperidol reducing naloxegol clearance.
What to do
Monitor for gastrointestinal effects and opioid withdrawal symptoms. Reduce the naloxegol dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Naloxegol
- Clarithromycin + Naloxegol Contraindicated
- Itraconazole + Naloxegol Contraindicated
- Ketoconazole + Naloxegol Contraindicated
- Naloxegol + Posaconazole Contraindicated
- Naloxegol + Voriconazole Contraindicated
- Bupropion-naltrexone + Naloxegol Major
Frequently asked questions
Can I take Haloperidol with Naloxegol?
MediHelp rates the interaction as moderate. Haloperidol and Naloxegol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Naloxegol is a CYP3A4 substrate and haloperidol may weakly inhibit this enzyme, possibly increasing naloxegol exposure. Higher levels may cause abdominal pain, diarrhea and opioid withdrawal symptoms.
How serious is the interaction between Haloperidol and Naloxegol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal effects and opioid withdrawal symptoms. Reduce the naloxegol dose if adverse effects appear.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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