Drug interactions
Haloperidol + Nebivolol
Severity: Moderate
Haloperidol and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol inhibits CYP2D6 to a modest degree and may raise nebivolol concentrations. Additive hypotension may also occur, so bradycardia and low blood pressure are the main concerns.
What this interaction means in plain words
Haloperidol and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Nebivolol belongs to Cardiovascular.
Why it happens
Haloperidol inhibits CYP2D6 metabolism of nebivolol, with additive hypotensive effects from alpha-blockade.
What to do
Monitor heart rate and blood pressure when combining the drugs. Lower the nebivolol dose if bradycardia or hypotension appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Nebivolol?
MediHelp rates the interaction as moderate. Haloperidol and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol inhibits CYP2D6 to a modest degree and may raise nebivolol concentrations. Additive hypotension may also occur, so bradycardia and low blood pressure are the main concerns.
How serious is the interaction between Haloperidol and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when combining the drugs. Lower the nebivolol dose if bradycardia or hypotension appears.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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