Drug interactions
Haloperidol + Oliceridine
Severity: Major
Haloperidol and Oliceridine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, and combining them with an opioid increases sedation and respiratory depression. Haloperidol, a CYP2D6 inhibitor, may also raise oliceridine exposure, and both can prolong the QT interval.
What this interaction means in plain words
Haloperidol and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Haloperidol belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression, with CYP2D6 inhibition by haloperidol and additive QT effects.
What to do
Reserve for patients without alternatives, use reduced opioid doses and monitor respiratory rate, sedation and QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Haloperidol with Oliceridine?
MediHelp rates the interaction as major. Haloperidol and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs depress the central nervous system, and combining them with an opioid increases sedation and respiratory depression. Haloperidol, a CYP2D6 inhibitor, may also raise oliceridine exposure, and both can prolong the QT interval.
How serious is the interaction between Haloperidol and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve for patients without alternatives, use reduced opioid doses and monitor respiratory rate, sedation and QTc.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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