Drug interactions
Haloperidol + Oxymorphone
Severity: Moderate
Haloperidol and Oxymorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol and opioids together may produce additive sedation, hypotension and respiratory depression. Haloperidol inhibits CYP2D6, but this has little effect on oxymorphone, which is cleared mainly by glucuronidation.
What this interaction means in plain words
Haloperidol and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Oxymorphone belongs to Musculoskeletal.
Why it happens
Additive CNS depression; CYP2D6 inhibition is of minor relevance.
What to do
Use low initial doses and monitor sedation and respiratory status. Adjust doses according to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Oxymorphone?
MediHelp rates the interaction as moderate. Haloperidol and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol and opioids together may produce additive sedation, hypotension and respiratory depression. Haloperidol inhibits CYP2D6, but this has little effect on oxymorphone, which is cleared mainly by glucuronidation.
How serious is the interaction between Haloperidol and Oxymorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use low initial doses and monitor sedation and respiratory status. Adjust doses according to clinical response.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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