Drug interactions
Haloperidol + Pemigatinib
Severity: Moderate
Haloperidol and Pemigatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pemigatinib is a CYP3A4 substrate. Haloperidol is only a weak inhibitor, so the increase in exposure is expected to be small, but may worsen hyperphosphatemia-related and other adverse effects.
What this interaction means in plain words
Haloperidol and Pemigatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Pemigatinib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by haloperidol reducing pemigatinib clearance.
What to do
Monitor for pemigatinib adverse effects and serum phosphate. Adjust the dose per labeling if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Pemigatinib
Frequently asked questions
Can I take Haloperidol with Pemigatinib?
MediHelp rates the interaction as moderate. Haloperidol and Pemigatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pemigatinib is a CYP3A4 substrate. Haloperidol is only a weak inhibitor, so the increase in exposure is expected to be small, but may worsen hyperphosphatemia-related and other adverse effects.
How serious is the interaction between Haloperidol and Pemigatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for pemigatinib adverse effects and serum phosphate. Adjust the dose per labeling if toxicity occurs.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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