Drug interactions
Haloperidol + Pexidartinib
Severity: Moderate
Haloperidol and Pexidartinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib is metabolized by CYP3A4 and can cause serious liver injury. Haloperidol is a weak inhibitor so the rise in exposure may be small, but it could add to hepatotoxicity risk.
What this interaction means in plain words
Haloperidol and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Pexidartinib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by haloperidol reducing pexidartinib clearance.
What to do
Monitor liver enzymes regularly as required for pexidartinib. Reduce the dose or stop if hepatotoxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Haloperidol and Pexidartinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Pexidartinib
Frequently asked questions
Can I take Haloperidol with Pexidartinib?
MediHelp rates the interaction as moderate. Haloperidol and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pexidartinib is metabolized by CYP3A4 and can cause serious liver injury. Haloperidol is a weak inhibitor so the rise in exposure may be small, but it could add to hepatotoxicity risk.
How serious is the interaction between Haloperidol and Pexidartinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes regularly as required for pexidartinib. Reduce the dose or stop if hepatotoxicity develops.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
