Drug interactions
Haloperidol + Quizartinib
Severity: Major
Haloperidol and Quizartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, so using them together raises the chance of marked QTc prolongation and torsades de pointes. Quizartinib labeling carries a boxed warning for QT prolongation, which makes this additive risk clinically important.
What this interaction means in plain words
Haloperidol and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Haloperidol belongs to Central Nervous System; Quizartinib belongs to Oncology.
Why it happens
Additive blockade of cardiac potassium (hERG) channels leading to delayed ventricular repolarization.
What to do
Avoid the combination where possible, or obtain a baseline ECG and repeat ECGs regularly during coadministration. Correct potassium and magnesium abnormalities and stop or switch one agent if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Quizartinib
- Quizartinib + Thioridazine Contraindicated
- Quizartinib + Ziprasidone Contraindicated
- Alfuzosin + Quizartinib Major
- Amiodarone + Quizartinib Major
- Amitriptyline + Quizartinib Major
- Amobarbital + Quizartinib Major
Frequently asked questions
Can I take Haloperidol with Quizartinib?
MediHelp rates the interaction as major. Haloperidol and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval, so using them together raises the chance of marked QTc prolongation and torsades de pointes. Quizartinib labeling carries a boxed warning for QT prolongation, which makes this additive risk clinically important.
How serious is the interaction between Haloperidol and Quizartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or obtain a baseline ECG and repeat ECGs regularly during coadministration. Correct potassium and magnesium abnormalities and stop or switch one agent if QTc becomes markedly prolonged.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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