Drug interactions
Haloperidol + Sertraline
Severity: Moderate
Haloperidol and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline inhibits CYP2D6, mildly to moderately at usual doses, which can raise haloperidol concentrations. Both drugs can prolong the QT interval, so arrhythmia and extrapyramidal effects may be more likely.
What this interaction means in plain words
Haloperidol and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by sertraline plus additive QT prolongation.
What to do
Use the lowest effective haloperidol dose and monitor ECG, electrolytes and extrapyramidal symptoms. Reduce the haloperidol dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Sertraline?
MediHelp rates the interaction as moderate. Haloperidol and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sertraline inhibits CYP2D6, mildly to moderately at usual doses, which can raise haloperidol concentrations. Both drugs can prolong the QT interval, so arrhythmia and extrapyramidal effects may be more likely.
How serious is the interaction between Haloperidol and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective haloperidol dose and monitor ECG, electrolytes and extrapyramidal symptoms. Reduce the haloperidol dose if adverse effects appear.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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