Drug interactions
Haloperidol + Sufentanil
Severity: Moderate
Haloperidol and Sufentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an opioid with an antipsychotic increases sedation and can add to respiratory depression and hypotension. The risk is greatest with high opioid doses or in frail patients.
What this interaction means in plain words
Haloperidol and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Sufentanil belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression, with alpha-adrenergic blockade adding to hypotension.
What to do
Use the lowest effective doses and monitor sedation, respiratory rate and blood pressure. Reduce the opioid dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Haloperidol with Sufentanil?
MediHelp rates the interaction as moderate. Haloperidol and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an opioid with an antipsychotic increases sedation and can add to respiratory depression and hypotension. The risk is greatest with high opioid doses or in frail patients.
How serious is the interaction between Haloperidol and Sufentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation, respiratory rate and blood pressure. Reduce the opioid dose as needed.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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