Drug interactions
Haloperidol + Sumatriptan
Severity: Minor
Haloperidol and Sumatriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Serotonin syndrome has been reported rarely when triptans are combined with other serotonergic or psychotropic drugs. With haloperidol the risk is low and mainly theoretical.
What this interaction means in plain words
Haloperidol and Sumatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Haloperidol belongs to Central Nervous System; Sumatriptan belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects; mechanism is not well established.
What to do
No routine change is needed; counsel the patient to report agitation, fever, tremor, or rigidity and stop treatment if serotonin toxicity is suspected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Frequently asked questions
Can I take Haloperidol with Sumatriptan?
MediHelp rates the interaction as minor. Haloperidol and Sumatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Serotonin syndrome has been reported rarely when triptans are combined with other serotonergic or psychotropic drugs. With haloperidol the risk is low and mainly theoretical.
How serious is the interaction between Haloperidol and Sumatriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; counsel the patient to report agitation, fever, tremor, or rigidity and stop treatment if serotonin toxicity is suspected.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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