Drug interactions
Haloperidol + Tamsulosin
Severity: Moderate
Haloperidol and Tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol is a substrate and modest inhibitor of CYP2D6 and CYP3A4 and may modestly raise tamsulosin exposure. Both drugs can cause orthostatic hypotension, so additive hypotensive effects are plausible.
What this interaction means in plain words
Haloperidol and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Tamsulosin belongs to Genitourinary.
Why it happens
Haloperidol may inhibit CYP2D6 and CYP3A4, and both drugs have additive alpha-adrenergic blocking effects.
What to do
Monitor blood pressure and orthostatic symptoms, particularly in older patients. Reduce the tamsulosin dose if dizziness or falls occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Tamsulosin?
MediHelp rates the interaction as moderate. Haloperidol and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol is a substrate and modest inhibitor of CYP2D6 and CYP3A4 and may modestly raise tamsulosin exposure. Both drugs can cause orthostatic hypotension, so additive hypotensive effects are plausible.
How serious is the interaction between Haloperidol and Tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, particularly in older patients. Reduce the tamsulosin dose if dizziness or falls occur.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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