Drug interactions
Haloperidol + Tranylcypromine
Severity: Moderate
Haloperidol and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol is a potent dopamine blocker, and together with an MAO inhibitor there is a theoretical risk of NMS, serotonin toxicity and hypotension. Co-prescription occurs in practice and serious reactions are uncommon.
What this interaction means in plain words
Haloperidol and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
Additive dopaminergic and monoaminergic pharmacodynamic effects.
What to do
Monitor for rigidity, fever, autonomic instability and mental status change, and check blood pressure. Discontinue both agents and treat if NMS or serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Tranylcypromine?
MediHelp rates the interaction as moderate. Haloperidol and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol is a potent dopamine blocker, and together with an MAO inhibitor there is a theoretical risk of NMS, serotonin toxicity and hypotension. Co-prescription occurs in practice and serious reactions are uncommon.
How serious is the interaction between Haloperidol and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for rigidity, fever, autonomic instability and mental status change, and check blood pressure. Discontinue both agents and treat if NMS or serotonin syndrome is suspected.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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