Drug interactions
Haloperidol + Vardenafil
Severity: Moderate
Haloperidol and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol prolongs the QT interval and vardenafil may add a small effect, increasing arrhythmia risk. Haloperidol is also a weak CYP3A4 inhibitor, though this is unlikely to change vardenafil exposure markedly.
What this interaction means in plain words
Haloperidol and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Vardenafil belongs to Genitourinary.
Why it happens
Additive prolongation of cardiac repolarization, with possible minor CYP3A4 inhibition.
What to do
Use the lowest effective doses and correct potassium and magnesium abnormalities. Obtain a baseline ECG in patients with cardiac disease or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Vardenafil?
MediHelp rates the interaction as moderate. Haloperidol and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol prolongs the QT interval and vardenafil may add a small effect, increasing arrhythmia risk. Haloperidol is also a weak CYP3A4 inhibitor, though this is unlikely to change vardenafil exposure markedly.
How serious is the interaction between Haloperidol and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and correct potassium and magnesium abnormalities. Obtain a baseline ECG in patients with cardiac disease or other QT-prolonging drugs.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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