Drug interactions
Haloperidol + Venetoclax
Severity: Moderate
Haloperidol and Venetoclax: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venetoclax is a CYP3A substrate, and haloperidol is a weak CYP3A4 inhibitor. Any increase in venetoclax exposure is probably small but could add to neutropenia and tumor lysis risk.
What this interaction means in plain words
Haloperidol and Venetoclax can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Venetoclax belongs to Miscellaneous.
Why it happens
Haloperidol may inhibit CYP3A4, reducing venetoclax metabolism.
What to do
Monitor blood counts and tumor lysis parameters, especially during dose ramp-up. Consider another antipsychotic if toxicity increases.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Venetoclax
- Clarithromycin + Venetoclax Contraindicated
- Itraconazole + Venetoclax Contraindicated
- Ketoconazole + Venetoclax Contraindicated
- Posaconazole + Venetoclax Contraindicated
- Venetoclax + Voriconazole Contraindicated
- Amiodarone + Venetoclax Major
Frequently asked questions
Can I take Haloperidol with Venetoclax?
MediHelp rates the interaction as moderate. Haloperidol and Venetoclax can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venetoclax is a CYP3A substrate, and haloperidol is a weak CYP3A4 inhibitor. Any increase in venetoclax exposure is probably small but could add to neutropenia and tumor lysis risk.
How serious is the interaction between Haloperidol and Venetoclax?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and tumor lysis parameters, especially during dose ramp-up. Consider another antipsychotic if toxicity increases.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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