Drug interactions
Haloperidol + Voxelotor
Severity: Moderate
Haloperidol and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 and can raise exposure to sensitive CYP3A4 substrates. Haloperidol is partly metabolized by CYP3A4, so higher levels may increase sedation, extrapyramidal effects and QT prolongation.
What this interaction means in plain words
Haloperidol and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibits CYP3A4, reducing haloperidol metabolism.
What to do
Monitor for extrapyramidal symptoms, sedation and QTc prolongation, and consider reducing the haloperidol dose. Obtain an ECG if other QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Haloperidol with Voxelotor?
MediHelp rates the interaction as moderate. Haloperidol and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor inhibits CYP3A4 and can raise exposure to sensitive CYP3A4 substrates. Haloperidol is partly metabolized by CYP3A4, so higher levels may increase sedation, extrapyramidal effects and QT prolongation.
How serious is the interaction between Haloperidol and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, sedation and QTc prolongation, and consider reducing the haloperidol dose. Obtain an ECG if other QT risk factors are present.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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