Drug interactions
Hemin + Prednisolone
Severity: Moderate
Hemin and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hemin is used to treat acute porphyria attacks by suppressing hepatic delta-aminolevulinic acid synthase. Corticosteroids can induce this enzyme and may promote porphyrin production, potentially opposing hemin's benefit.
What this interaction means in plain words
Hemin and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hemin belongs to Miscellaneous; Prednisolone belongs to Endocrine.
Why it happens
Steroids may induce hepatic ALA synthase, which hemin acts to repress, giving pharmacodynamic antagonism.
What to do
Monitor the clinical response and porphyrin precursor levels during an acute attack. Avoid unnecessary steroid use in porphyria patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Other interactions of Hemin
- Hemin + Secobarbital Major
- Argatroban + Hemin Moderate
- Bazedoxifene-conjugated estrogens + Hemin Moderate
- Dabigatran etexilate + Hemin Moderate
- Dalteparin + Hemin Moderate
- Desogestrel-ethinyl estradiol + Hemin Moderate
Frequently asked questions
Can I take Hemin with Prednisolone?
MediHelp rates the interaction as moderate. Hemin and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hemin is used to treat acute porphyria attacks by suppressing hepatic delta-aminolevulinic acid synthase. Corticosteroids can induce this enzyme and may promote porphyrin production, potentially opposing hemin's benefit.
How serious is the interaction between Hemin and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the clinical response and porphyrin precursor levels during an acute attack. Avoid unnecessary steroid use in porphyria patients.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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