Drug interactions
Henbane + Prochlorperazine
Severity: Moderate
Henbane and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Henbane contains belladonna alkaloids such as hyoscyamine and scopolamine, which add to the anticholinergic effects of prochlorperazine. This can cause confusion, dry mouth, constipation, urinary retention and tachycardia, and can reduce gut motility.
What this interaction means in plain words
Henbane and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects through pharmacodynamic synergism.
What to do
Avoid the combination in older adults and in patients with glaucoma, ileus or urinary retention. Otherwise monitor for anticholinergic toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Henbane with Prochlorperazine?
MediHelp rates the interaction as moderate. Henbane and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Henbane contains belladonna alkaloids such as hyoscyamine and scopolamine, which add to the anticholinergic effects of prochlorperazine. This can cause confusion, dry mouth, constipation, urinary retention and tachycardia, and can reduce gut motility.
How serious is the interaction between Henbane and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in older adults and in patients with glaucoma, ileus or urinary retention. Otherwise monitor for anticholinergic toxicity.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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