Drug interactions
Heparin + Liothyronine
Severity: Minor
Heparin and Liothyronine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid hormones increase catabolism of vitamin K-dependent clotting factors, which strengthens oral anticoagulant effect. With heparin the effect is not well established and is likely small.
What this interaction means in plain words
Heparin and Liothyronine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Heparin belongs to Cardiovascular; Liothyronine belongs to Endocrine.
Why it happens
Thyroid hormone accelerates clotting factor turnover, a mechanism relevant mainly to warfarin; effect on heparin is uncertain.
What to do
Monitor aPTT or anti-Xa as part of routine heparin therapy, especially when thyroid doses change.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Other interactions of Liothyronine
- Alogliptin-metformin + Liothyronine Moderate
- Amitriptyline + Liothyronine Moderate
- Amobarbital + Liothyronine Moderate
- Canagliflozin-metformin + Liothyronine Moderate
- Carbamazepine + Liothyronine Moderate
- Carbonyl iron + Liothyronine Moderate
Frequently asked questions
Can I take Heparin with Liothyronine?
MediHelp rates the interaction as minor. Heparin and Liothyronine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thyroid hormones increase catabolism of vitamin K-dependent clotting factors, which strengthens oral anticoagulant effect. With heparin the effect is not well established and is likely small.
How serious is the interaction between Heparin and Liothyronine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor aPTT or anti-Xa as part of routine heparin therapy, especially when thyroid doses change.
What other medicines interact with Heparin?
MediHelp also lists interactions of Heparin with, for example, Defibrotide, Ketorolac, Oritavancin. The full list is on the Heparin page.
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