Drug interactions
Heparin + Nintedanib
Severity: Moderate
Heparin and Nintedanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nintedanib inhibits VEGFR and has been associated with an increased risk of bleeding. Concurrent full-dose heparin may further raise this risk.
What this interaction means in plain words
Heparin and Nintedanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Heparin belongs to Cardiovascular; Nintedanib belongs to Oncology.
Why it happens
VEGFR inhibition by nintedanib impairs vascular integrity and hemostasis, adding to heparin anticoagulation.
What to do
Use in patients on full anticoagulation only if the benefit outweighs the risk, and monitor closely for bleeding. Adjust or interrupt therapy if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Other interactions of Nintedanib
- Amiodarone + Nintedanib Moderate
- Apixaban + Nintedanib Moderate
- Argatroban + Nintedanib Moderate
- Azithromycin + Nintedanib Moderate
- Carbamazepine + Nintedanib Moderate
- Carvedilol + Nintedanib Moderate
Frequently asked questions
Can I take Heparin with Nintedanib?
MediHelp rates the interaction as moderate. Heparin and Nintedanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nintedanib inhibits VEGFR and has been associated with an increased risk of bleeding. Concurrent full-dose heparin may further raise this risk.
How serious is the interaction between Heparin and Nintedanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use in patients on full anticoagulation only if the benefit outweighs the risk, and monitor closely for bleeding. Adjust or interrupt therapy if bleeding occurs.
What other medicines interact with Heparin?
MediHelp also lists interactions of Heparin with, for example, Defibrotide, Ketorolac, Oritavancin. The full list is on the Heparin page.
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