Drug interactions
Heparin + Tibolone
Severity: Minor
Heparin and Tibolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tibolone has weak hormonal activity and may modestly affect coagulation and fibrinolysis, with thromboembolic risk reported in some settings. There is no well-documented potentiation of heparin's effect.
What this interaction means in plain words
Heparin and Tibolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Heparin belongs to Cardiovascular; Tibolone belongs to Endocrine.
Why it happens
Not clearly established; possible minor effects of tibolone on coagulation and fibrinolytic parameters.
What to do
No routine adjustment; monitor aPTT or anti-Xa as usual and review the need for tibolone in patients with active thromboembolism.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Other interactions of Tibolone
- Amobarbital + Tibolone Moderate
- Carbamazepine + Tibolone Moderate
- Secobarbital + Tibolone Moderate
- Alogliptin-metformin + Tibolone Minor
- Argatroban + Tibolone Minor
- Dapagliflozin-metformin + Tibolone Minor
Frequently asked questions
Can I take Heparin with Tibolone?
MediHelp rates the interaction as minor. Heparin and Tibolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tibolone has weak hormonal activity and may modestly affect coagulation and fibrinolysis, with thromboembolic risk reported in some settings. There is no well-documented potentiation of heparin's effect.
How serious is the interaction between Heparin and Tibolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor aPTT or anti-Xa as usual and review the need for tibolone in patients with active thromboembolism.
What other medicines interact with Heparin?
MediHelp also lists interactions of Heparin with, for example, Defibrotide, Ketorolac, Oritavancin. The full list is on the Heparin page.
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