Drug interactions
Secobarbital + Tibolone
Severity: Moderate
Secobarbital and Tibolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzyme-inducing barbiturates may reduce tibolone metabolite levels, possibly lessening relief of menopausal symptoms and endometrial protection.
What this interaction means in plain words
Secobarbital and Tibolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Secobarbital belongs to Central Nervous System; Tibolone belongs to Endocrine.
Why it happens
Barbiturate induction of hepatic enzymes increases tibolone metabolism.
What to do
Monitor for recurrence of menopausal symptoms or abnormal bleeding and consider an alternative sedative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Tibolone
- Amobarbital + Tibolone Moderate
- Carbamazepine + Tibolone Moderate
- Alogliptin-metformin + Tibolone Minor
- Argatroban + Tibolone Minor
- Dapagliflozin-metformin + Tibolone Minor
- Empagliflozin-metformin + Tibolone Minor
Frequently asked questions
Can I take Secobarbital with Tibolone?
MediHelp rates the interaction as moderate. Secobarbital and Tibolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzyme-inducing barbiturates may reduce tibolone metabolite levels, possibly lessening relief of menopausal symptoms and endometrial protection.
How serious is the interaction between Secobarbital and Tibolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for recurrence of menopausal symptoms or abnormal bleeding and consider an alternative sedative.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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