Drug interactions
Amobarbital + Tibolone
Severity: Moderate
Amobarbital and Tibolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturate enzyme induction may reduce tibolone's active metabolite levels, possibly weakening symptom relief or endometrial protection.
What this interaction means in plain words
Amobarbital and Tibolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Tibolone belongs to Endocrine.
Why it happens
Hepatic enzyme induction increases metabolism of tibolone.
What to do
Monitor for return of menopausal symptoms or abnormal bleeding, and consider an alternative to the barbiturate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Tibolone
- Carbamazepine + Tibolone Moderate
- Secobarbital + Tibolone Moderate
- Alogliptin-metformin + Tibolone Minor
- Argatroban + Tibolone Minor
- Dapagliflozin-metformin + Tibolone Minor
- Empagliflozin-metformin + Tibolone Minor
Frequently asked questions
Can I take Amobarbital with Tibolone?
MediHelp rates the interaction as moderate. Amobarbital and Tibolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturate enzyme induction may reduce tibolone's active metabolite levels, possibly weakening symptom relief or endometrial protection.
How serious is the interaction between Amobarbital and Tibolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for return of menopausal symptoms or abnormal bleeding, and consider an alternative to the barbiturate.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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