Drug interactions
Carbamazepine + Tibolone
Severity: Moderate
Carbamazepine and Tibolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine may reduce tibolone metabolite concentrations, potentially causing loss of symptom relief or breakthrough bleeding. Evidence is largely extrapolated from other enzyme inducers.
What this interaction means in plain words
Carbamazepine and Tibolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Tibolone belongs to Endocrine.
Why it happens
Carbamazepine induces CYP3A4, increasing metabolism of tibolone and its active metabolites.
What to do
Monitor for recurrence of menopausal symptoms or irregular bleeding. Consider a different therapy if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Tibolone
- Amobarbital + Tibolone Moderate
- Secobarbital + Tibolone Moderate
- Alogliptin-metformin + Tibolone Minor
- Argatroban + Tibolone Minor
- Dapagliflozin-metformin + Tibolone Minor
- Empagliflozin-metformin + Tibolone Minor
Frequently asked questions
Can I take Carbamazepine with Tibolone?
MediHelp rates the interaction as moderate. Carbamazepine and Tibolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine may reduce tibolone metabolite concentrations, potentially causing loss of symptom relief or breakthrough bleeding. Evidence is largely extrapolated from other enzyme inducers.
How serious is the interaction between Carbamazepine and Tibolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for recurrence of menopausal symptoms or irregular bleeding. Consider a different therapy if efficacy is lost.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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