Drug interactions
Hepatitis a / b vaccine + Lomustine
Severity: Moderate
Hepatitis a / b vaccine and Lomustine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomustine suppresses immune function and can reduce the antibody response to this inactivated combined vaccine. Seroprotection may not be achieved.
What this interaction means in plain words
Hepatitis a / b vaccine and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic suppression of lymphocytes and bone marrow reduces vaccine-induced immune response.
What to do
Complete vaccination at least 2 weeks before lomustine if possible; otherwise check antibody titers or revaccinate after immune recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Hepatitis a / b vaccine with Lomustine?
MediHelp rates the interaction as moderate. Hepatitis a / b vaccine and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomustine suppresses immune function and can reduce the antibody response to this inactivated combined vaccine. Seroprotection may not be achieved.
How serious is the interaction between Hepatitis a / b vaccine and Lomustine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete vaccination at least 2 weeks before lomustine if possible; otherwise check antibody titers or revaccinate after immune recovery.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.
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