Drug interactions
Hepatitis a / b vaccine + Secukinumab
Severity: Minor
Hepatitis a / b vaccine and Secukinumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inactivated vaccines are not contraindicated with secukinumab, but the antibody response may be reduced in treated patients. Secukinumab has been shown to permit adequate responses to some inactivated vaccines, so the effect is likely modest.
What this interaction means in plain words
Hepatitis a / b vaccine and Secukinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
IL-17A inhibition may modestly blunt immune responses, though humoral responses to inactivated vaccines are largely preserved.
What to do
Complete age-appropriate immunizations before starting secukinumab when feasible; consider checking anti-HBs titers after hepatitis B vaccination in at-risk patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Secukinumab
- Adenovirus types 4 and 7 live + Secukinumab Major
- Bcg vaccine live + Secukinumab Major
- Influenza virus vaccine quadrivalent intranasal + Secukinumab Major
- Measles mumps and rubella vaccine live + Secukinumab Major
- Measles mumps and rubella vaccine + Secukinumab Major
- Measles mumps rubella and varicella vaccine live + Secukinumab Major
Frequently asked questions
Can I take Hepatitis a / b vaccine with Secukinumab?
MediHelp rates the interaction as minor. Hepatitis a / b vaccine and Secukinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Inactivated vaccines are not contraindicated with secukinumab, but the antibody response may be reduced in treated patients. Secukinumab has been shown to permit adequate responses to some inactivated vaccines, so the effect is likely modest.
How serious is the interaction between Hepatitis a / b vaccine and Secukinumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete age-appropriate immunizations before starting secukinumab when feasible; consider checking anti-HBs titers after hepatitis B vaccination in at-risk patients.
What other medicines interact with Secukinumab?
MediHelp also lists interactions of Secukinumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Secukinumab page.
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